Argireline Review


Unlike many specific anti-wrinkle products that we look at here, Argireline is actually a patented peptide complex that is currently used as an ingredient by numerous beauty product manufacturers. Argireline, which goes under the scientific name of Acetyl Hexapeptide-3, is manufactured by Lipotec. Lipotec is a Barcelona-based cosmetics research lab. It is interesting to note that some of the products that feature Argireline as an active ingredient also sell themselves as “made in the USA,” neglecting the fact that Argireline’s real point of origin is in Europe.

So what’s so great about Argireline? The peptide is derived from natural proteins, and claims to actually relax facial muscles to the point of paralysis. This goes well with the company’s “like Botox without the hassle” claims. The theory guiding both products is that relaxed facial muscles will minimize current wrinkles caused by repetitive muscle contractions, as well as prevent new wrinkles. Muscle contractions are guided by a chemical reaction called the “SNAP receptor complex,” and Argireline is specifically designed to interfere with this reaction.

Product Details

With so many anti-wrinkle creams produced by multiple manufacturers all using Argireline, what’s the difference? For starters, different Argireline-based products use different concentrated solutions of the product. Despite what users might think, a higher concentration solution of Argireline may not be best. Lipotec’s own product trials show that a solution concentrated at 5%-10% has been most effective to date. Before buying an Argireline-based product, try to determine what concentration of the peptide is included. Although raw Argireline is available straight from Lipotec, it is only intended for industrial use and users should not try to formulate their own products at home.

Argireline can currently be found in creams, serums and eye creams. One caution about this peptide is that, like with many cutting edge technologies, long terms effects of consistent Argireline exposure have yet to be observed.

The Good

  • Available in many different products from many different manufacturers.
  • There is a lot of research available regarding this product.
  • Claims to mimic the muscle relaxing properties of Botox with topical application.

The Bad

  • Effects of long-term use are still unknown.
  • Lipotec, who conducted a lot of the quality research on Argireline, have no say regarding the products in which this peptide is used.
  • Not all Argireline products may feature the peptide in its ideal concentration.
  • Not available directly from manufacturer.

The Bottom Line

Argireline certainly seems to be a potent medicine. However, we’d be a bit more comfortable with it if we knew how it might effect skin in the long term. That’s always a factor when looking at new “cosmeceutical” products. Additionally, the use of Argireline by third party product manufacturers is completely unregulated. We’ve seen some products that will use Lipotec’s Argireline testing data as a validation of their own creams and lotions. However, there is obviously no guarantee that these products are even including an ideal concentration of Argireline in its product, much less how the peptide will react with other included ingredients. There’s definitely a lot of “miracle” potential in Argireline, but we’d be sure to thoroughly research any product that features it before purchasing.


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